What antidepressants can I take with Contrave (naltrexone/bupropion)?

It is important that your medical provider review any antidepressants you are currently taking before prescribing Contrave®. Contrave contains the antidepressant Wellbutrin® (bupropion), so if you are already taking Wellbutrin, it is not recommended to add Contrave. Depending on your medical history and medications you are taking, the combination of Contrave with other antidepressants may increase the risk for seizures. Certain antidepressants known as monoamine oxidase inhibitors (MAOis) (e.g. selegiline, isocarboxazid, phenelzine, and tranylcypromine) are contraindicated in combination with Contrave. If you have recently stopped taking a MAOi, you must wait at least 2 weeks before starting Contrave. Lastly, if you are currently taking Contrave, make sure to discuss this with your medical provider before taking any new antidepressant medication.

ABOUT THE AUTHOR

Lauren Lemieux, MD, FACP, ABOM diplomate

‍Dr. Lauren Lemieux completed her Internal Medicine residency and fellowship in Clinical Nutrition at UCLA. She is board certified in Internal Medicine and diplomate of the American Board of Obesity Medicine, and as a Physician Nutrition Specialist. She is also a fellow of the American College of Physicians. Dr. Lemieux is passionate about helping her patients reach their health goals using personalized nutrition, lifestyle and weight management strategies.

Doctor, healthy food, man on a computer , and smiling women sitting on counter in baggy yellow sweatshirt

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Contrave® is a registered trademark of Currax Pharmaceutical LLC

Wellbutrin® is a registered trademark of GlaxoSmithKline, LCC