How much weight can you lose on Zepbound (tirzepatide)?

The amount of weight a person can lose when taking Zepbound® depends on a variety of factors. Keep in mind that Zepbound is FDA-approved for individuals with a body mass index (BMI) of 30 or higher or 27 or higher with a weight related medical condition such as diabetes, high blood pressure, high cholesterol, etc. and is to be used in combination with a low calorie nutrition plan and increased physical activity. In a clinical trial, participants taking the highest dose of Zepbound (15 mg) lost an average of ~22% of their starting body weight on the medication, which was the equivalent of approximately 50 lbs. That being said, individual responses to the medication will vary. Typically, when starting a weight loss medication we look for at least 5% weight loss after 3 months on the medication. If a person has not reached that benchmark, it’s less likely that this is an effective medication for that person, and alternative treatment options should be considered. If you are taking Zepbound and struggling to lose weight, please discuss this with your medical provider.

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ABOUT THE AUTHOR

Form Health

Form Health is a virtual obesity medicine clinic founded in 2019 that provides science-based obesity care to help patients achieve their weight loss and health goals. Patients have the opportunity to achieve sustainable weight loss by working closely with an American Board of Obesity Medicine physician and a Registered Dietitian who is a Board Certified Specialist in Obesity and Weight Management. Each Care Team develops a personalized treatment plan based on a comprehensive review of their medical history that includes behavioral support, nutrition, physical activity, and medication, if appropriate.

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Zepbound® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.